• 文献标题:   Graphene Quantum Dots-Band-Aids Used for Wound Disinfection
  • 文献类型:   Article
  • 作  者:   SUN HJ, GAO N, DONG K, REN JS, QU XG
  • 作者关键词:   graphene quantum dot, peroxidaselike activity, antibacterial system, bandaid, wound disfenction
  • 出版物名称:   ACS NANO
  • ISSN:   1936-0851 EI 1936-086X
  • 通讯作者地址:   Univ Chinese Acad Sci
  • 被引频次:   221
  • DOI:   10.1021/nn501640q
  • 出版年:   2014

▎ 摘  要

Herein, an antibacterial system combining the "safe" carbon nanomaterials, graphene quantum dots (GQDs), with a low level of H2O2 has been put forward. It has been found that the peroxidase-like activity of GQDs originates from their ability to catalyze the decomposition of H2O2, generating center dot OH. Since the center dot OH has a higher antibacterial activity, the conversion of H2O2 into center dot OH improves the antibacterial performance of H2O2, which makes it possible to avoid the toxicity of H2O2 at high levels in wound disinfection. All the experiments in vitro display that this intrinsic activity exerts a high enhancement of antibacterial activity of H2O2, and the designed system possessed broad spectrum of antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. More importantly, to assess the antibacterial efficacy of the designed system in actual wound disinfection, the GOD-Band-Aids are prepared and show excellent antibacterial property with the assistance of H2O2 at low dose in vivo.