▎ 摘　　要

To realize the long-term release property of drugs, reduce the cytotoxicity of anti-cancer drugs and improve the heat stability of the growth factor, a heparin-modified graphene oxide (Hep-GO) was prepared through a click reaction between azide-modified graphene oxide and propargylamine-modified heparin. Then, the Hep-GO was used as a carrier of doxorubicin hydrochloride (DOX) and granulocyte colony stimulating factor (G-CSF), and a Hep-GO/DOX/G-CSF complex was fabricated. UV-Vis analysis was carried out to study the colloidal stability of Hep-GO in aqueous solution. A thermogravimetric test was used to determine its composition. Then, the loading process, in vitro release behavior, heat stability and cytotoxicity of the Hep-GO/DOX/G-CSF complex were studied. The results showed that the Hep-GO/DOX/G-CSF complex displayed heat stability, long-term drug release property and lower drug cytotoxicity, suggesting the great potential application of Hep-GO as a multifunctional drug delivery system.