▎ 摘　　要

The current research is focused on the electrochemical determination of dexamethasone (DEX) in pharmaceutical samples and the production of ZnO and graphene oxide nanocomposite modified screen-printed electrodes (ZnO@GO/SPE) utilizing a simple chemical technique. According to XRD and SEM investigations, the hexagonal crystal structure of GO nanosheets of hexagonal wurtzite ZnO nanorods was successfully combined into a sandwich-like ZnO@GO nanocomposite structure. ZnO@GO/SPE is a selective, more stable, and sensitive DEX sensor than ZnO/SPE and GO/SPE, according to electrochemical tests employing DPV and amperometry techniques. Because of its good stability and large accessible specific surface area for analyte adsorption from electrolyte, the ZnO@GO nanocomposite had a linear range of 10 to 200 mu M, sensitivity of 0.20211 mu A/mu M, and a limit of detection of 12 nM, which showed comparable or even better sensing performance than other reported DEX sensors in the literature. This improved the charge transfer between the electrode and the analyte of ZnO@GO nanocomposite. e practical capability of the ZnO@GO/SPE was tested for determining DEX level in dexamethasone injection, and the results showed that the recovery (96.50% to 99.16%) and RSD (3.33% to 4.35%) values were appropriate for practical analyses in clinical and pharmaceutical samples, indicating appropriate validity and accuracy.