▎ 摘　　要

Under ultrasound irradiation, 17 examples of 2-Amino-3-cyano-4H-chromene derivatives were prepared via one-pot three components domino Knoevenagel-Michael condensation reaction of aliphatic/aromatic/heterocyclic aldehydes, malononitrile, and alpha-naphthol/beta-naphthol/resorcinol in the presence of Fe3O4-supported sulfonated graphene oxide as a green and magnetically separable nanocatalyst in H2O: EtOH (1:1) solvent system. FT-IR, TGA, SEM, and XRD were used to evaluate the catalyst. The current protocol is appealing because of high atom economy (95%), excellent yields (88-95%), its short reaction time, waste-free conditions, cost-effectiveness, use of a nontoxic solvent, lack of high temperature for reflux, non-chromatographic purification of products, recyclability of catalyst, etc. In-silico studies were conducted on the selected proteins DNA gyrase (1KZN) and CYP51 (4WMZ) to study the docking interactions with highest docking scores 4h (-8.8 kcal/mol) and 4e (-10.1 kcal/mol), respectively. ADME and Toxicity analysis of docked compounds and reference drugs were also done.