• 文献标题:   Reinforcing effect of graphene oxide reinforcement on the properties of poly (vinyl alcohol) and carboxymethyl tamarind gum based phase-separated film
  • 文献类型:   Article
  • 作  者:   YADAV I, NAYAK SK, RATHNAM VSS, BANERJEE I, RAY SS, ANIS A, PAL K
  • 作者关键词:   polyvinyl alcohol, carboxymethyl tamarind gum, graphene oxide, film, viscoelastic, drug release, antimicrobial activity, cell proliferation
  • 出版物名称:   JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
  • ISSN:   1751-6161 EI 1878-0180
  • 通讯作者地址:   Natl Inst Technol
  • 被引频次:   7
  • DOI:   10.1016/j.jmbbm.2018.02.021
  • 出版年:   2018

▎ 摘  要

The current study deals with the preparation and the characterization of the PVA-CMT-GO films. The PVA-CMT film was translucent in nature and smooth to touch. The addition of GO resulted in the formation of agglomerated structures. XRD studies suggested that the incorporation of GO increased the average crystallite size. The mechanical properties of the films as determined by stress relaxation studies suggested that all the films were viscoelastic in nature. The drug release study showed a decrease in the amount of the drug release with the increase in the GO content. The PVA-CMT-GO films (without drug) showed certain degree of antimicrobial activity owing to the inherent antimicrobial property of GO. The drug loaded films also showed good antimicrobial property. It was found that the prepared films altered the cell proliferation of the human skin keratinocytes in a composition-dependent manner.