▎ 摘　　要

Preventing human islet amyloid polypeptide (hIAPP) fibrillogenesis has been a primary strategy in development of therapeutic drugs for type II diabetes. In this study, we prepared stable GO-PEI complex by modification of polyetherimide (PEI) on the surface of graphene oxide (GO) using covalent binding method. The results of transmission electron microscopy (TEM) and circular dichroism (CD) show that GO-PEI is more efficient than GO in inhibiting hIAPP fibril formation. The ThT fluorescence assay and atomic force microscopy (AFM) image data show that GO-PEI is the most effective for the inhibition of hIAPP fibrillation when it is added at the initial stage of hIAPP aggregation, and less effective when added in the growing period of hIAPP aggregation, but the inhibitor disables to disrupt the matured hIAPP fibrils. The findings may provide information valuable to the research and development of GO-based inhibitors.