• 文献标题:   Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: Designed for targeted and controlled doxorubicin delivery
  • 文献类型:   Article
  • 作  者:   POURJAVADI A, TEHRANI ZM, JOKAR S
  • 作者关键词:   doxorubicin, magnetic graphene oxide, mesoporous silica, polyglycerol, polycaprolactone
  • 出版物名称:   JOURNAL OF INDUSTRIAL ENGINEERING CHEMISTRY
  • ISSN:   1226-086X EI 1876-794X
  • 通讯作者地址:   Sharif Univ Technol
  • 被引频次:   23
  • DOI:   10.1016/j.jiec.2015.01.021
  • 出版年:   2015

▎ 摘  要

In the present work a novel multifunctional drug nanocarrier was prepared. Polyglycerol-g-polycaprolactone was grafted on Mesoporous silica-coated magnetic graphene oxide. Doxorubicin, as anticancer drug, was loaded on this carrier. The in vitro drug release showed the controlled pH responsive behavior. At the endosomal pH (pH 5.5) the amount of drug release enhanced. This nanocarrier would have potential application in the tumor therapy owing to its biodegradability, controlled release and pH responsive behavior. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.