▎ 摘　　要

A sonochemical assisted preparation of zirconium dioxide (ZrO2) sheathed reduced graphene oxide (ZrO2@rGO NCs) nanocomposites as the highly sensitive electrode material for the detection of oxidative stress biomarker 3-Nitro-l-tyrosine (3-NT) was reported. The formation of prepared ZrO2@rGO NCs and its surface morphology were scrutinized by the X-ray photoelectron spectroscopy (XPS) and Field emission scanning electron microscope (FE-SEM). Moreover, the as-prepared nanocomposites were fabricated on the glassy carbon electrode (GCE), and its electrochemical performance towards the detection of 3-NT are studied by the various electrochemical techniques such as Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and amperometric (i-t). The excellent conductivity of the rGO and the electrocatalytic properties of the ZrO2 significantly improves the electrochemical performances. As a result, the ZrO2@rGO NCs display the LOD of 9 nM with the covering range of 0.025 to 855.2 mu M towards the detection of 3-NT. Finally, the real-time practicability of ZrO2@rGO NCs in the spiked human serum and saliva samples also investigated, which shows the feasible found and recoveries. Hence, this study sonochemically prepared ZrO2@rGO NCs provides the simple, rapid and efficient towards the detection of 3-NT in biological samples. (C) 2020 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.