▎ 摘　　要

MCs is a group of potent hepatotoxic peptides produced by cyanobacterial in eutrophic water, among which microcystin-LR is the most abundant and toxic. Long-time accumulation of even trace dosage from drinking water would cause significantly hepatic injury to animal and humans. Here we reported a novel Cu2+-modified mesoporous silica coated magnetic graphene composite (magG@mSiO(2)@-Cu2+) through mild sol-gel process and surface modification. Next, the composites were successfully applied for enrichment and separation of microcystin-LR followed by MALDI-TOF MS analysis based on the virtues of excellent hydrophilicity, high surface area (261 cm(2) g(-1)), sensitively magnetic separation property, accessible porosity (3.10 nm) and large amount of modified Cu2+ ions. Even performed in a lower concentration (0.5 mu g/L), at which microcystin-LR could not be detected directly, after treatment with the composites the S/N ratio could appear to be 82.93. Furthermore, the novel composites also exhibited high enrichment efficiency in real water sample. It provided a sensitive and efficient technique for enrichment and detection of microcystin-LR and developed a potent method for separation of pollutant in contaminated water. (c) 2016 Elsevier B.V. All rights reserved.