▎ 摘　　要

Carbon nanotube, graphene and carbon black, as electrode modifiers, were compared and evaluated for the electrochemical determination of vancomycin. Among them, the best results were obtained at the graphene-modified electrode. Additions of vancomycin using square wave voltammetry at the graphene-modified electrode showed a linear range from 0.70 mu M to 50 mu M and a detection limit of 0.20 mu M was obtained. To control the correct dose of vancomycin and reduce its side effects, its accurate determination in blood plasma is very important. Therefore, the method was applied for the vancomycin determination in spiked human plasma samples and satisfactory recoveries were observed. The developed method exhibited fast analysis, high sensitivity, good repeatability and freedom from other interfering species.