• 文献标题:   Preparation and characterization of zinc modified calcium silicate/ polycaprolactone with graphene oxide composite coating for bone repair applications
  • 文献类型:   Article
  • 作  者:   SASIREKA A, SUGANTHI S, VIGNESH S, RAJ V, OH TH
  • 作者关键词:   biomaterial, bone tissue regeneration, calcium silicate, polycaprolactone, cell viability, antibacterial activity
  • 出版物名称:   CERAMICS INTERNATIONAL
  • ISSN:   0272-8842 EI 1873-3956
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1016/j.ceramint.2023.03.148 EA MAY 2023
  • 出版年:   2023

▎ 摘  要

The goal of biomaterial interest is the ease of the bone tissue regeneration process or the replacement of damaged bone and other tissues with recently generated bone tissue. Calcium silicate (CaSi) bioceramic is a vital material for bone tissue engineering, predominantly for bone repair. Though, the low toughness of calcium silicate imitates its load-bearing applications. The electrophoretic deposition technique was used to coat various concentrations of Zn2+ substituted CaSi on TNT. In this work, a novel as-obtained an appropriate orthopedic implant hybrid material by charged calcium ions of mineralized calcium silicate united with PCL-negatively charged graphene oxide [Zn-CaSi (S-1-S-3)/PCL (P-1-P-3)/GO]. Hence, the effectively as-obtained [Zn-CaSi (S-1-S-3)/PCL (P1P3)/GO] bone-like apatite on the ternary composite coatings on the surface was proven via XRD, FT-IR, FESEM with EDAX spectra, HR-TEM and BET analyses etc., Moreover, the TNT/S-2/P-2@GO ternary composite coatings exhibit better mechanical properties and antibacterial activity. The metal ions released from the coatings were calculated via ICP-AES studies. Moreover, the cell viability and also the live/dead staining of MG63 human osteoblasts cells on the subsequent composite coating material for better cell growth in orthopedic applications.