▎ 摘　　要

The heterostructures of two-dimensional (2D) materials have broad application prospects in surface plasmon resonance (SPR) biosensor. In order to enhance the sensitivity, we propose new a configuration of SPR biosensor based on Cu/Au/Ag-indium tin oxide (ITO)-graphene/two-dimensional transition metal dichalcogenide (TMDC) hybrid structures for highly sensitive sensors. The highest angular sensitivity with 219.4 degrees/RIU for the Ag-ITO-WS2 is obtained. In addition, the SPR biosensor can also be used to detect analytes with different refractive index. The phase sensitivity of Cu-ITO-MoSe2 structure is 30.18 times higher than that of the single Cu thin film and 1.51 times higher than that of the Cu-ITO hybrid structure. It is believed that the SPR sensor has potential application prospects in environmental monitoring, chemical examination, and biological and gas detection.