• 文献标题:   Electrochemical Sensor for Simultaneous Determination of Theophylline and Caffeine Based on a Novel poly (folic acid)/graphene Composite Film Modified Electrode
  • 文献类型:   Article
  • 作  者:   SHU XL, BIAN F, WANG QQ, QIN XF, WANG Y
  • 作者关键词:   folic acid, graphene, chemically modified electrode, theophylline, caffeine
  • 出版物名称:   INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
  • ISSN:   1452-3981
  • 通讯作者地址:   Shandong Normal Univ
  • 被引频次:   5
  • DOI:   10.20964/2017.05.37
  • 出版年:   2017

▎ 摘  要

In this work, a novel poly(folic acid)/graphene composite film modified electrode was developed to construct an electrochemical sensor for simultaneous determination of theophylline (TP) and caffeine (CAF). The fabrication and characterization of nanocomposite film were investigated in details by electrochemistry and scanning electron microscopy. This new electrochemical sensor displayed superior electrocatalytic property to the oxidation of TP and CAF, which obviously improved the sensitive detection of the two compounds in the terms of high sensitivity and wide linear range. Under the optimized experimental conditions, the detection limits were obtained to be 0.03 mu mol L-1 for TP and 0.08 mu mol L-1 for CAF, respectively. The novel sensor was successfully used for the simultaneous detection of TP and CAF in food samples.