▎ 摘　　要

In the present study, the electrochemical behavior of an anorexiant drug, sibutramine (SHM), was studied at an electro-reduced graphene oxide film modified glassy carbon electrode (ERGO-GCE) for the first time. SHM exhibited two irreversible oxidation peaks at 0.620 V and 0.835 V in Britton-Robinson buffer in the pH range 3-10. The first peak and second peak were found to result from adsorption and diffusion controlled processes, respectively. ERGO-GCE exhibited excellent electrocatalytic activity for the oxidation of SHM. Under optimized experimental conditions, the oxidation peak (a(2)) current was observed to be proportional to the concentration of SHM up to 2.00 x 10(-5) mol L-1 with a limit of detection of 4.80 x 10(-8) mol L-1. The proposed sensor was successfully applied for the assay of SHM in analyte fortified human serum and urine samples. No interference was evident from endogenous substances present in biological fluids.