• 文献标题:   Synthesis and characterization of PEGylated iron and graphene oxide magnetic composite for curcumin delivery
  • 文献类型:   Article
  • 作  者:   ABBASI R, AMJAD JM, NOSRATI H, MOHAMMADKHANI R, DANAFAR H
  • 作者关键词:   composite, curcumin, graphene oxide, magnetic nanoparticle
  • 出版物名称:   APPLIED ORGANOMETALLIC CHEMISTRY
  • ISSN:   0268-2605 EI 1099-0739
  • 通讯作者地址:   Univ Zanjan
  • 被引频次:   0
  • DOI:   10.1002/aoc.5825 EA JUN 2020
  • 出版年:   2020

▎ 摘  要

Nowadays, nanostructures have been given significant attention in medical and biological fields. Among these nanostructures, graphene oxide (GO) has been widely used in drug delivery systems, because of its unique properties, and the ability to connect to other nanostructures such as magnetic nanoparticles (NPs) as well as polymers by its functional groups. In this research, first, GO was prepared by exfoliating graphite according to the modified Hummer's method, and then the Fe(3)O(4)NPs were synthesized by a simple co-precipitation method on GO nanosheets. In the next step, with the help of the ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide coupling reagents, the polyethylene glycol (PEG) polymer was bonded to the GO-Fe(3)O(4)nanocomposite. Finally, anti-cancer drug, curcumin (Cur) was loaded onto the nanocomposite and the Cur loading ratio was measured at about 8%. The samples were evaluated using Fourier transform-infrared, differential scanning calorimtery, vibrating-sample magnetometry, atomic force microscopy and dynamic light scattering techniques. The results show that the prepared nanocomposite is an appropriate candidate for biomedical applications.