▎ 摘　　要

Surface plasmon resonance (SPR) is an emerging technology in the field of biosensors owing to its label-free and real-time detection of different biosamples. In this research, a highly sensitive optimized SPR sensor is designed with 2D materials like black phosphorous (BP) and graphene and proposed for refractive index sensing in the range 1.41 to 1.45, which corresponds to brain tumor cells. The finite element method (FEM) with the help of COMSOL Multiphysics software is employed for analysis of reflectivity and electric field near the sensing layer. The number of layers of BP and graphene are judiciously optimized to achieve maximum sensing performance and high evanescent field. The outcomes of the proposed sensor revealed that a maximum sensitivity of 324.25 deg./RIU, figure of merit of 34.025, and detection accuracy of 0.134 1/deg. are achieved in sensing refractive index in the range 1.41 to 1.45. So, the designed sensor can find suitable applications in biomedical industries.