• 文献标题:   Graphene oxide-stabilized perfluorocarbon emulsions for controlled oxygen delivery
  • 文献类型:   Article
  • 作  者:   JALANI G, JEYACHANDRAN D, CHURCH RB, CERRUTI M
  • 作者关键词:  
  • 出版物名称:   NANOSCALE
  • ISSN:   2040-3364 EI 2040-3372
  • 通讯作者地址:   McGill Univ
  • 被引频次:   6
  • DOI:   10.1039/c7nr00378a
  • 出版年:   2017

▎ 摘  要

Perfluorocarbon (PFC) emulsions are capable of absorbing large quantities of oxygen. They are widely used as blood alternates for quick oxygenation of tissues. However, they are unsuitable for applications where sustained oxygen supply is desired over an extended period of time. Here, we have designed a new PFC oxygen delivery system that combines perfluorodecalin with graphene oxide (GO), where GO acts both as an emulsifier and a stabilizing agent. The resulting emulsions (PFC@GO) release oxygen at least one order of magnitude slower than emulsions prepared with other common surfactants. The release rate can be controlled by varying the thickness of the GO layer. Controlled release of oxygen make these emulsions excellent oxygen carriers for applications where sustained oxygen delivery is required e.g. in tissue regeneration and vascular wound healing.