• 文献标题:   Ultrasound-accelerated synthesis of gold nanoparticles modified choline chloride functionalized graphene oxide as a novel sensitive bioelectrochemical sensor: Optimized meloxicam detection using CCD-RSM design and application for human plasma sample
  • 文献类型:   Article
  • 作  者:   BAHRANI S, RAZMI Z, GHAEDI M, ASFARAM A, JAVADIAN H
  • 作者关键词:   bioelectrochemical sensor, gold nanoparticle, choline chloride, graphene oxide, meloxicam, plasma
  • 出版物名称:   ULTRASONICS SONOCHEMISTRY
  • ISSN:   1350-4177 EI 1873-2828
  • 通讯作者地址:   Univ Yasuj
  • 被引频次:   5
  • DOI:   10.1016/j.ultsonch.2017.12.042
  • 出版年:   2018

▎ 摘  要

In this research, gold nanoparticles modified choline chloride functionalized graphene oxide (AuNPs-ChCl-GO) was synthesized through the assistance of ultrasound and fabricated as a novel bioelectrochemical sensor and utilized for the sensitive detection of meloxicam (MEL). The morphological and structural features of the AuNPs-ChCl-GO were characterized using different techniques including FTIR, TEM, FE-SEM, EDX, and XRD. The modified electrode showed a remarkable improvement in the anodic oxidation activity of MEL due to the enhancement in the current response compared to the bare carbon paste electrode (CPE). The biosensor composition and measurement conditions were optimized using an experimental design. The differential pulse voltammetry (DPVs) exhibited expanded linear dynamic in the range of 9.0 x 10(-9) to 8.5 x 10(-7) M for MEL in Britton-Robinson buffer at pH = 4.0 with a detection limit of 1.008 x 10(-9) M. The practical utility of the modified electrode was demonstrated by the accurate detection of MEL in human plasma sample.