▎ 摘　　要

A stable composite film of silver nanoparticles (Ag NPs) decorated on reduced graphene oxide is prepared by a two-step simple procedure. The surface morphology of the modified electrode is characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. The electrochemical behavior of tinidazole (TNZ) on the surface of the modified electrode is investigated by linear sweep voltammetry and electrochemical impedance spectroscopy. The prepared composite electrode acts as a highly sensitive platform for the voltammetric determination of TNZ, leading to a significant increase in the reduction peak current of TNZ. The effects of experimental parameters such as the amount of the casted silver ions-GO mixture suspension, the electro-reduction variables, the accumulation time and potential, the scan rate and pH of the buffered solutions on the electrochemical response of TNZ are investigated. Under optimal conditions, the modified electrode showed a wide linear range for the reduction of TNZ in the range of 0.01-10 mu M with a detection limit of 3 nM. Finally, the prepared electrode is successfully applied for the determination of TNZ in pharmaceutical and clinical samples.