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  • 文献标题:   Sensitive determination of uric acid by using graphene quantum dots as a new substrate for immobilisation of uric oxidase
  • 文献类型:   Article, Proceedings Paper
  • 作　　者:   YU HW, ZHANG Z, SHEN T, JIANG JH, CHANG D, PAN HZ
  • 作者关键词:   organic compound, graphene device, quantum dot, enzyme, biosensor, biochemistry, electrochemical electrode, electrochemical sensor, transmission electron microscopy, scanning electron microscopy, voltammetry chemical analysis, electrochemical impedance spectroscopy, nanomedicine, molecular biophysic, sensitive uric acid determination, graphene quantum dot, uric oxidase immobilisation, electrochemical detection, gqd, enzyme immobilisation, glassy carbon electrode, gce, transmission electron microscope, scanning electron microscopy, cyclic voltammetry, electrochemical impedance spectroscopy, electrochemical biosensor, c
  • 出版物名称:   IET NANOBIOTECHNOLOGY
  • ISSN:   1751-8741 EI 1751-875X
  • 通讯作者地址:   Fudan Univ
  • 被引频次:   1
  • DOI:   10.1049/iet-nbt.2016.0221
  • 出版年:   2018

▎ 摘　　要

A novel strategy for highly sensitive electrochemical detection of uric acid (UA) was proposed based on graphene quantum dots (GQDs), GQDs were introduced as a suitable substrate for enzyme immobilisation. Uric oxidase (UOx) was immobilised on GQDs modified glassy carbon electrode (GCE). Transmission electron microscope, scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy techniques were used for characterising the electrochemical biosensor. The developed biosensor responds efficiently to UA presence over the concentration linear range 1-800M with the detection limit 0.3M. This novel biosensing platform based on UOx/GQDs electrode responded even more sensitively than that based on GCE modified by UOx alone. The inexpensive, reliable and sensitive sensing platform based on UOx/GQDs electrode provides wide potential applications in clinical.