▎ 摘　　要

This work exploits the applicability of a chemically reduced graphene oxide (CRGO) modification on the electrochemical response of a glassy carbon electrode (GCE) for the first-time sensitive determination of furosemide in natural waters. The batch injection analysis (BIA) is proposed as an analytical method, where CRGO-GCE is coupled to a BIA cell for amperometric measurements. Acetate buffer (0.1 mu mol L-1, pH 5.2) was used as the background electrolyte. The modification provided an increase in sensitivity (0.024 mu A/mu mol L-1), low limit of detection (0.7 mu mol L-1), RSD (< 4%), and broad linear range (1-600 mu mol L-1). Recovery tests performed in two different concentration ranges resulted in values between 89 and 99%. Recovery tests were performed and compared with high-performance liquid chromatography (HPLC) with UV-Vis detection using Student'sttest at a 95% significance level, and no significant differences were found, confirming the accuracy of the method. The developed method is proven faster (169 h(-1)) compared with the HPLC analysis (5 h(-1)), also comparable with other flow procedures hereby described, offering a low-cost strategy suitable to quantify an emerging pharmaceutical pollutant.