• 文献标题:   Optimized polylactic acid/polyethylene glycol (PLA/PEG) electrospun fibrous scaffold for drug delivery: effect of graphene oxide on the cefixime release mechanism
  • 文献类型:   Article
  • 作  者:   NAZARI T, MOGHADDAM AB, DAVOODI Z
  • 作者关键词:   pla, peg fibrous scaffold, graphene oxide, cefixime, sustained release, rsm optimization analysi, drug release mechanism
  • 出版物名称:   MATERIALS RESEARCH EXPRESS
  • ISSN:   2053-1591
  • 通讯作者地址:   Univ Tehran
  • 被引频次:   3
  • DOI:   10.1088/2053-1591/ab508d
  • 出版年:   2019

▎ 摘  要

In the recent decade, there has been a growing interest in using electrospun polymeric scaffolds for sustained release of drugs. In this work, fibrous scaffolds of polylactic acid/polyethylene glycol (PLA/PEG) were prepared and characterized through scanning electron microscopy, for subsequent utilization as the drug delivery system for cefixime (CF). In this regard, the response surface experimental design (RSM) was successfully used for finding optimized electrospinning condition such as total solution concentration (Ctot