• 文献标题:   Preparation of small-sized graphene oxide sheets and their biological applications
  • 文献类型:   Article
  • 作  者:   ZHANG MF, OKAZAKI T, IIZUMI Y, MIYAKO E, YUGE R, BANDOW S, IIJIMA S, YUDASAKA M
  • 作者关键词:  
  • 出版物名称:   JOURNAL OF MATERIALS CHEMISTRY B
  • ISSN:   2050-750X EI 2050-7518
  • 通讯作者地址:   Natl Inst Adv Ind Sci Technol
  • 被引频次:   11
  • DOI:   10.1039/c5tb01800e
  • 出版年:   2016

▎ 摘  要

By using carbon nanohorns as starting materials, small- and uniform-sized graphene oxide (S-GO) sheets can be prepared in high yields via an oxidation method. The obtained S-GO sheets have a band-like structure with a length of 20-50 nm, a width of 2-10 nm, and a thickness of 0.5-5 nm. S-GO sheets are hydrophilic due to abundant oxygenated groups on the surfaces and edges; hence, this nanomaterial is highly dispersive in aqueous solutions and some hydrophilic organic solvents. Additionally, like other S-GO samples, the S-GO sheets prepared here are strongly fluorescent over the visible light wavelength region. These characteristics underscore the high potential of S-GO sheets for nanomedical and diagnostic applications. In proof-of-concept experiments, the S-GO sheets were conjugated with an arginine-glycine-aspartic acid derivative for tumour-targeting drug delivery applications, and with an immunoglobulin G antibody for immunoassay applications.