• 文献标题:   Magnetic graphene oxide mesoporous silica hybrid nanoparticles with dendritic pH sensitive moieties coated by PEGylated alginate-co-poly (acrylic acid) for targeted and controlled drug delivery purposes
  • 文献类型:   Article
  • 作  者:   POURJAVADI A, SHAKERPOOR A, TEHRANI ZM, BUMAJDAD A
  • 作者关键词:   drug delivery system, stimulisensitive polymer, phsensitive nanoparticle, pegylated sodium alginate, mcm41 mesoporous silica
  • 出版物名称:   JOURNAL OF POLYMER RESEARCH
  • ISSN:   1022-9760 EI 1572-8935
  • 通讯作者地址:   Sharif Univ Technol
  • 被引频次:   4
  • DOI:   10.1007/s10965-015-0799-y
  • 出版年:   2015

▎ 摘  要

In this study synthesis of a drug delivery system (DDS) is described which has several merits over its counterparts. In order to synthesize this nano-carrier, graphene oxide nano-sheets are used to accommodate MCM-41 nanoparticles. Furthermore Fe3O4 nanoparticles are introduced to this nanomaterial to produce a traceable nanoparticle. Since cancerous tissues have lower pH than healthy tissues, pH-sensitive oligomers are attached to this nano-material. Finally the nano-carrier is wrapped by a biocompatible shell (PEGylated sodium alginate); this polymeric shell makes the DDS capable of a more controllable drug release. Bymeasuring in vitro situation, 'loading content%' and 'entrapment efficiency%' proves to be 21 and 93.5 % respectively. In an acidic medium, the drug carrier without a polymeric shell (naked DDS) releases the whole of its drug content in 18 h, while the drug carrier with a polymeric shell (core-shell DDS) releases 45 % of its drug content during 48 h.