• 文献标题:   Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repair
  • 文献类型:   Article
  • 作  者:   SAFARI N, GOLAFSHAN N, KHARAZIHA M, TOROGHINEJAD MR, UTOMO L, MALDA J, CASTILHO M
  • 作者关键词:   magnesium alloy, degradation, corrosion resistance, antibacterial propertie, bone implant
  • 出版物名称:   ACS BIOMATERIALS SCIENCE ENGINEERING
  • ISSN:   2373-9878
  • 通讯作者地址:   Isfahan Univ Technol
  • 被引频次:   0
  • DOI:   10.1021/acsbiomaterials.0c00613
  • 出版年:   2020

▎ 摘  要

Magnesium (Mg)-based alloys are promising biodegradable materials for bone repair applications. However, due to their rapid degradation and high corrosion rate, Mg-based alloys are typically associated with in vivo infections and implant failure. This study evaluated the synergistic stability and anti-inflammatory properties that could potentially be achieved by the modification of the Mg alloy with graphene nanoparticles (Gr). Incorporation of low dosages of Gr (0.18 and 0.50 wt %) in a Mg alloy with aluminum (Al, 1 wt %) and copper (Cu, 0.25 wt %) was successfully achieved by a spark plasma sintering (SPS) method. Notably, the degradation rate of the Mg-based alloys was reduced approximately 4fold and the bactericidal activity was enhanced up to 5-fold with incorporation of only 0.18 wt % Gr to the Mg-1Al-Cu matrix. Moreover, the modified Mg-based nanocomposites with 0.18 wt % Gr demonstrated compressive properties within the range of native cancellous bone (modulus of approximately 6 GPa), whereas in vitro studies with human mesenchymal stromal cells (hMSCs) showed high cytocompatibility and superior osteogenic properties compared to non-Gr-modified Mg-1Al-Cu implants. Overall, this study provides foundations for the fabrication of stable, yet fully resorbable, Mg-based bone implants that could reduce implant-associated infections.