• 文献标题:   Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier
  • 文献类型:   Article
  • 作  者:   KHATAMIAN M, DIVBAND B, FARAHMANDZAHED F
  • 作者关键词:   drug carrier system, biocompatibility, doxorubicin, in vitro cytotoxicity, clinoptilolite
  • 出版物名称:   MATERIALS SCIENCE ENGINEERING CMATERIALS FOR BIOLOGICAL APPLICATIONS
  • ISSN:   0928-4931 EI 1873-0191
  • 通讯作者地址:   Tabriz Univ Med Sci
  • 被引频次:   23
  • DOI:   10.1016/j.msec.2016.04.090
  • 出版年:   2016

▎ 摘  要

Current research has focused on the preparation of Zinc-clinoptilolite/Graphene Oxide (Zn-Clin/GO) hybrid nanostructure and investigating its biocompatibility for the first time. As prepared samples were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Thermo gravimetric analysis (TGA) and Fourier transform infrared (FT-IR). In order to use it as a drug carrier two important factors were investigated: cytocompatibility of nanocomposites and their drug loading capacity. The results showed that the prepared nanocomposite is cytocompatible and its high loading capacity and slow release performance for Doxorubicin (DOX), as a cancer drug, proved that it can be used as a drug carrier. At last in-vitro toxicity of DOX loaded nano composite was compared with pure DOX. (C) 2016 Elsevier B.V. All rights reserved.