▎ 摘　　要

Simultaneous voltammetry determination of pentoxifylline (PTX) and paracetamol (PAR) were investigated by using graphene nanoflakes modified glassy carbon electrode (GrNF/GCE) in drug and biological samples. The synthesized flake was characterized using various analytical methods and the electron transfer behavior of GrNF was confirmed by CV and EIS techniques. Electrocatalytic oxidation of PTX and PAR at GrNF/GCE occurred at a potential of +1.220V and + 0.190V. The peak to peak separation (900 mV) was obtained for PTX and PAR at GrNF/GCE using DPV method. Amperometry technique was carried out to measure the current response of PTX and PAR and its dynamic ranges from 0.2 x 10(-8)-300 x 10(-6) M (0.9938) and 0.1 x 10(-8)-150 x 10(-6) M (0.9982). The LOD of PTX and PAR were determined to be 0.75 and 0.43 nM (S/N = 3), respectively. This system provides high-level sensitivity in the presence of an excess concentration of easily oxidizable interfering biological molecules and it shows a better reproducibility and repeatability. The present system has been effectively applied for the PTX and PAR determination in real samples. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.