▎ 摘　　要

Self-healable hydrogels are promising soft materials with great potential in biomedical applications due to their autonomous self-repairing capability. Although many attempts are made to develop new hydrogels with good self-healing performance, to integrate this characteristic along with other responsive multifunctions into one hydrogel still remains difficult. Here, a self-healable hybrid supramolecular hydrogel (HSH) with tunable bioadhesive and stimuli-responsive properties is reported. The strategy is imparting graphene oxide (GO) nanosheets and quadruple hydrogen bonding ureido-pyrimidinone (UPy) moieties into a thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) polymer matrix. The obtained GO-HSH hydrogel shows rapid self-healing behavior and good adhesion to various surfaces from synthetic materials to biological tissue. In addition, doxorubicin hydrochloride (DOX) release profiles reveal the dual thermo- and pH-responsiveness of the GO-HSH hydrogel. The DOX-loaded hydrogel can further directly adhere to titanium substrate, and the released DOX from this thin hydrogel coating remains biologically active and has high capability to kill tumor cells.