▎ 摘　　要

In this study, graphene oxide (GO) was functionalized with polyethylene glycol (PEG) via amidation reaction. Furthermore, temozolomide (TMZ) was loaded onto GO-PEG via pi-pi stacking and hydrophobic interactions. The successful synthesis of GO-PEG nanocarrier and GO-PEG-TMZ were characterized by UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscope (SEM). Drug loading and releasing experiments demonstrate the GO-PEG has a good loading capacity of (6.47 +/- 0.08) mg/mg for TMZ and a satisfactory accumulative release rate of 71.12% in 12 h under slightly acidic condition. The CCK-8 assay demonstrated that TMZ and GO-PEG-TMZ had significant inhibitory effects on rat glioma cells, and showed a dose-dependent characteristic, while the inhibition of GO-PEG composite was weak. The feature of loading and delivering anti-tumor drugs using GO-PEG-based carrier may provide potential applications in biomedical therapy.