▎ 摘　　要

A facile and sensitive electrochemical sensor based on glassy carbon electrode (GCE) modified with beta cyclodextrin (beta-CD) functionalized porous reduced graphene oxide (prGO) was fabricated and used for electrochemical determination of dihydrochalcone, phloretin in biological samples. Low temperature solution combustion method was employed to fabricate prGO from graphene oxide. The product so obtained was mixed with beta-CD and treated for ultra sonication in order to get beta-CD-prGO. Enhanced electrochemical response for phloretin (PHL) was observed at beta-CD-prGO modified GCE. The effect of pH, scan rate, accumulation time and amount of modifier on the electrochemical behavior of PHL was studied. The probable electro-oxidation mechanism was proposed based on obtained experimental results. Linearity between the peak current and concentration of PHL was noticed in the range of 0.1-75.2 mu M and 0.5-65.25 mu M for square wave and differential pulse voltammetric methods, respectively. The developed methods were successfully applied for the determination of PHL in spiked biological samples. Further, prepared beta-CD-prGO modified GCE was used to understand the interaction between HSA and PHL. (C) 2018 The Electrochemical Society.