▎ 摘　　要

A novel drug carrier based on hydroxypropyl-beta-cyclodextrin (HP-beta-CD) modified carboxylated graphene oxide (GO-COOH) was designed to incorporate anti-cancer drug paclitaxel (PTX).The formulated nanomedicines were characterized by Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Results showed that PTX can be incorporated into GO-COO-HP-beta-CD nanospheres successfully, with an average diameter of about 100 nm. The solubility and stability of PTX-loaded GO-COO-HP-beta-CD nanospheres in aqueous media were greatly enhanced compared with the untreated PTX. The results of hemolysis test demonstrated that the drug-loaded nanospheres were qualified with good blood compatibility for intravenous use. In vitro antitumor activity was measured and results demonstrated that the incorporation of PTX into the newly developed GO-COO-HP-beta-CD carrier could confer significantly improved cytotoxicity to the nanosystem against tumor cells than single application of PTX. GO-COO-HP-beta-CD nanospheres may represent a promising formulation platform for a broad range of therapeutic agent, especially those with poor solubility. (C) 2016 Elsevier B.V. All rights reserved.