▎ 摘　　要

The determination of doxorubicin and topotecan as two important breast anticancer drugs with high side effects is significant in pharmaceutical samples. 2D nitrogen doped reduced graphene (NrG) nano-sheet and 1-methyl-3-octylimidazolium chloride (MOICI) were suggested as two high conductive modifiers for fabrication of anticancer drug sensor based carbon paste electrode (CPE). The electrical conductivity of NrG/MOICl/CPE as a new analytical approach was probed by voltatnmetric methods. The NrG/MOICl/CPE showed accelerating the exchange of electrons for oxidation of doxorubicin and this improving helps to simultaneous determination of doxorubicin and topotecan with separation gap of 315 mV. The NrG/MOICl/CPE as an anticancer sensor displayed detection limits of 3.1 nM and 0.27 pM for doxorubicin and topotecan, respectively. The NrG/MOICl/CPE was found to be practically applicable in the determination of doxorubicin and topotecan in drug samples. (C) 2018 Published by Elsevier B.V.