▎ 摘　　要

Discrimination of enantiomers poses a scientific challenge as the chemical and physical properties of enantiomers are nearly identical. The chiral analysis is usually performed by separation techniques, including chromatography, electrophoresis, or optical instrumentation based on an interaction of the analyzed sample with a polarized beam of light. Here we present a novel method for a chiral screening based on a combination of the black phosphorus@Graphene nanocomposite and Raman spectroscopy. The nanocomposite allows to enhance the Raman signal with factors higher than 100 asymmetrically and provide altered signals for mixtures containing varying enantiomeric ratios of target compounds. Tryptophan, Phenylalanine, DOPA, Isoleucine, and Leucine were selected as model compounds; the method allows us to discriminate between mixtures with 10, 25, 50, 75, and 100% enantiomeric purity. (C) 2020 Elsevier B.V. All rights reserved.