• 文献标题:   Graphene oxide enriched with oxygen-containing groups: on the way to an increase of antioxidant activity and biocompatibility
  • 文献类型:   Article
  • 作  者:   ABDELHALIM AOE, MESHCHERIAKOV AA, MAISTRENKO DN, MOLCHANOV OE, AGEEV SV, IVANOVA DA, IAMALOVA NR, LUTTSEV MD, VASINA LV, SHAROYKO VV, SEMENOV KN
  • 作者关键词:   graphene oxide, identification, biocompatibility, hsa, dpph, cytotoxicity
  • 出版物名称:   COLLOIDS SURFACES BBIOINTERFACES
  • ISSN:   0927-7765 EI 1873-4367
  • 通讯作者地址:  
  • 被引频次:   13
  • DOI:   10.1016/j.colsurfb.2021.112232 EA JAN 2022
  • 出版年:   2022

▎ 摘  要

The article is dedicated to the comprehensive biocompatibility investigation of synthesised graphene oxide (GO) enriched with oxygen-containing functional groups (similar to 85%). GO was synthesised through a modified Hummers and Offeman's method and characterised using C-13 NMR, Raman, and IR spectroscopy, XRD, HRTEM, along with size dimensions and zeta-potentials in aqueous dispersions. Biocompatibility study included tests on haemo-compatibility (haemolysis, platelet aggregation, binding to human serum albumin and its esterase activity), antioxidant activity (2,2-diphenyl-1-picrylhydrazyl reaction, NO-radical uptake, Radachlorin photobleaching, photo-induced haemolysis), genotoxicity using DNA comet assay, as well as metabolic activity and proliferation of HEK293 cells.