▎ 摘　　要

We reported on the one-pot synthesis of a ternary hybrid material composed of graphene functionalized with 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin, tin oxide, and gold nanoparticles. The composite was deposited on a glassy carbon electrode to give an electrode excellent electrocatalytic activity towards the oxidation of epinephrine (EP). The oxidation peaks for EP and uric acid (UA) occur at 190 and 322 mV, respectively, and thus are well separated. This allows for a simultaneous determination of EP and UA. Under optimal conditions, the linear response range in simultaneous determination of EP and UA is from 0.5 to 100 mu M for EP, and from 2.0 to 100 mu M for UA. The detection limits are at 50 nM for EP and at 500 nM for UA (at an S/N ratio of 3). The sensor was employed to quantify EP and UA in spiked urine samples with satisfactory results.