▎ 摘　　要

Acyclovir and valacyclovir are oxidized on a glassy carbon electrode (GCE) with immobilized reduced graphene oxide coated with a polyglycine film. We selected the conditions for forming a polymer film, reducing graphene oxide on the GCE, and recording the maximum catalytic current on the composite surface. A procedure was developed for the selective voltammetric determination of acyclovir and valacyclovir on an electrode with a reduced graphene oxide-polyglycine film composite. A method is proposed for the amperometric detection of guanine-based antiviral drugs with this modified electrode under the conditions of flow-injection analysis. The dependence of the analytical signal on the concentration of acyclovir and valacyclovir is linear up to 5 x 10(-6) M in the static mode and up to 1 x 10(-7) M in the flow-injection system. The developed voltammetric method for determining acyclovir and valacyclovir was tested in the analysis of pharmaceutical preparations.