▎ 摘　　要

The electrochemical behavior of hypocrellin A (HA) and graphene immobilized on electrochemically pretreated glassy carbon (GC) electrode by adsorption process was investigated. It underwent quasi-reversible redox reaction due to the central quinone functionalities of the HA molecule. The results were applied to develop a reagentless sensor for the indirect determination of aluminum (III) in biological fluids. The decrease of the differential pulse voltannmetry anodic peak current for HA ligand was linear with the increase of aluminum concentration. Various experimental parameters were optimized, which influenced the properties of the modified electrode. Under the optimum experimental conditions, the linear response range for Al (III) employing differential pulse voltammetry was 1.626 mu mol L-1 to 18.760 mu mol L-1 and the relative standard deviation for 1.626 mu mol L-1 Al (III) was 1.02% (n = 11). The detection limit was 0.497 mu mol L-1. the modified electrode, as a bio-compatibility sensor, was stable and portable. The methodological principle was Al (III) complexed with HA on the electroactive site resulting in the depression of electroactive HA. This method has been successfully applied to determine Al (III) in body fluid samples.