• 文献标题:   In Vitro Hyperthermia Evaluation of Electrospun Polymer Composite Fibers Loaded with Reduced Graphene Oxide
  • 文献类型:   Article
  • 作  者:   ZARATE IA, AGUILARBOLADOS H, YAZDANIPEDRAM M, PIZARRO GD, NEIRACARRILLO A
  • 作者关键词:   electrospun fiber, hyperthermia, electrospinning, polymer, nearinfrared radiation nir, thermally reduced graphene oxide trgo
  • 出版物名称:   POLYMERS
  • ISSN:  
  • 通讯作者地址:   Univ Chile
  • 被引频次:   0
  • DOI:   10.3390/polym12112663
  • 出版年:   2020

▎ 摘  要

Electrospun meshes (EM) composed of natural and synthetic polymers with randomly or aligned fibers orientations containing 0.5% or 1% of thermally reduced graphene oxide (TrGO) were prepared by electrospinning (ES), and their hyperthermia properties were evaluated. EM loaded with and without TrGO were irradiated using near infrared radiation (NIR) at 808 nm by varying the distance and electric potential recorded at 30 s. Morphological, spectroscopic, and thermal aspects of EM samples were analyzed by using SEM-EDS, Raman and X-ray photoelectron (XPS) spectroscopies, X-ray diffraction (XRD), and NIR radiation response. We found that the composite EM made of polyvinyl alcohol (PVA), natural rubber (NR), and arabic gum (AG) containing TrGO showed improved hyperthermia properties compared to EM without TrGO, reaching an average temperature range of 42-52 degrees C. We also found that the distribution of TrGO in the EM depends on the orientation of the fibers. These results allow infering that EM loaded with TrGO as a NIR-active thermal inducer could be an excellent candidate for hyperthermia applications in photothermal therapy.