▎ 摘　　要

Iron phthalocyanine (FePc) functionalized nitrogen, boron-doped reduced graphene oxide (N,B-rGO) nano-composite (FePc/N,B-rGO) was facilely fabricated for the first time as a electrochemical platform for sensitive detection of glutathione (GSH). FePc was immobilized on N,B-rGO substrate through pi-pi interaction, and N,B-rGO provided FePc with a large specific surface area to improve electron transfer and maintain its electrocatalytic activity. Cyclic voltammetric measurements showed that FePc and N,B-rGO triggered the synergistic effect and exhibited a satisfactory electrocatalytic activity. By integration of FePc and N,B-rGO, the FePc/N,B-rGO/GCE sensor displayed a wide linear dynamic range from 5.0 x 10(-8) M to 1.6 x 10(-3) M with a low detection limit of 7.1 x 10(-9) M. Besides, the electrochemical sensor presented satisfiable reproducibility, excellent anti-interference performance and long-term stability. The method was further expanded to determinate GSH in human serum sample with the recoveries between 95.0-109.0%.