• 文献标题:   Highly Sensitive and Selective Potassium Ion Detection Based on Graphene Hall Effect Biosensors
  • 文献类型:   Article
  • 作  者:   LIU XQ, YE C, LI XQ, CUI NY, WU TZ, DU SY, WEI QP, FU L, YIN JC, LIN CT
  • 作者关键词:   singlelayer graphene, hall effect biosensor, guaninerich dna strand, guaninequadruplexe, potassium ion
  • 出版物名称:   MATERIALS
  • ISSN:   1996-1944
  • 通讯作者地址:   Kunming Univ Sci Technol
  • 被引频次:   7
  • DOI:   10.3390/ma11030399
  • 出版年:   2018

▎ 摘  要

Potassium (K+) ion is an important biological substance in the human body and plays a critical role in the maintenance of transmembrane potential and hormone secretion. Several detection techniques, including fluorescent, electrochemical, and electrical methods, have been extensively investigated to selectively recognize K+ ions. In this work, a highly sensitive and selective biosensor based on single-layer graphene has been developed for K+ ion detection under Van der Pauw measurement configuration. With pre-immobilization of guanine-rich DNA on the graphene surface, the graphene devices exhibit a very low limit of detection (approximate to 1 nM) with a dynamic range of 1 nM-10 mu M and excellent K+ ion specificity against other alkali cations, such as Na+ ions. The origin of K+ ion selectivity can be attributed to the fact that the formation of guanine-quadruplexes from guanine-rich DNA has a strong affinity for capturing K+ ions. The graphene-based biosensors with improved sensing performance for K+ ion recognition can be applied to health monitoring and early disease diagnosis.