• 文献标题:   A study on graphene composites for peripheral nerve injury repair under electrical stimulation
  • 文献类型:   Article
  • 作  者:   HUANG ZQ, GUO ZZ, SUN MM, FANG SM, LI H
  • 作者关键词:  
  • 出版物名称:   RSC ADVANCES
  • ISSN:  
  • 通讯作者地址:   Jinan Univ
  • 被引频次:   1
  • DOI:   10.1039/c9ra04855c
  • 出版年:   2019

▎ 摘  要

Electrical stimulation (ES) provides an effective alternative to peripheral nerve repair via conductive scaffolds. The aim of the present study is to investigate a graphene (GR)/thermoplastic polyurethane (TPU) composite for the repair of peripheral nerve injury under ES. To this end, conductive composite membranes were fabricated by blending GR (2, 4 and 6 wt%) with TPU. GR maintains its own structure in the composite and enhances the mechanical and electrical properties of the composite. The composites with excellent biocompatibility had a hemolysis rate of less than 5%. As a result, the 4GR-TPU (4 wt% GR) sample with enhanced mechanical properties possessed the highest conductivity value of 33.45 +/- 0.78 S m(-1). Compared with the non-conductive sample, 4GR-TPU was favorable for the viability of Schwann cells (SCs) under ES. When different voltages of ES were applied, a direct current of 10 mV was more suitable for the growth and proliferation of SCs. This study provides beneficial information for peripheral nerve repair via ES.