• 文献标题:   Flow Sensing of Single Cell by Graphene Transistor in a Microfluidic Channel
  • 文献类型:   Article
  • 作  者:   ANG PK, LI A, JAISWAL M, WANG Y, HOU HW, THONG JTL, LIM CT, LOH KP
  • 作者关键词:   graphene, fieldeffect transistor, microfluidic, single cell detection, infectious disease, cell surface charge density
  • 出版物名称:   NANO LETTERS
  • ISSN:   1530-6984 EI 1530-6992
  • 通讯作者地址:   Singapore MIT Alliance Res Technol SMART
  • 被引频次:   75
  • DOI:   10.1021/nl202579k
  • 出版年:   2011

▎ 摘  要

The electronic properties of graphene are strongly influenced by electrostatic forces arising from long-range charge scatterers and by changes in the local dielectric environment. This makes graphene extremely sensitive to the surface charge density of cells interfacing with it Here, we developed a graphene transistor array integrated with microfluidic flow cytometry for the "flow-catch-release" sensing of malaria-infected red blood cells at the single-cell level. Malaria-infected red blood cells induce highly sensitive capacitively coupled changes in the conductivity of graphene. Together with the characteristic conductance dwell times, specific microscopic information about the disease state can be obtained.