• 文献标题:   Cytocompatible scaffolds of poly(L-lactide)/reduced graphene oxide for tissue engineering
  • 文献类型:   Article
  • 作  者:   DIAZ E, IGLESIAS N, RIBEIRO S, LANCEROSMENDEZ S
  • 作者关键词:   plla, rgo, hydrolysi, cytocompatible, bone regeneration
  • 出版物名称:   JOURNAL OF BIOMATERIALS SCIENCEPOLYMER EDITION
  • ISSN:   0920-5063 EI 1568-5624
  • 通讯作者地址:  
  • 被引频次:   7
  • DOI:   10.1080/09205063.2021.1922023 EA APR 2021
  • 出版年:   2021

▎ 摘  要

Poly(L-lactide)/reduced graphene oxide (PLLA/rGO) scaffolds were studied in the present work. The scaffolds were fabricated by TIPS (thermally induced phase separation). Nonisothermal crystallization study for PLLA/rGO was investigated and revealed the nucleating effect of rGO. rGO effect on cytotoxicity, thermal properties, and hydrolysis resistance of PLLA and PLLA/rGO scaffolds were analysed. In vitro degradation in phosphate-buffered solution at 37 degrees C is analyzed over twelve weeks. A high crystalline behaviour reduces the speed of hydrolysis and therefore implies less variation in pH, mass loss and water up take. The rGO does not seem to accelerate the degradation process. Finally, rGO contents in PLLA up to 1 wt% dos not lead to cytotoxic effect, the scaffolds supporting cell adhesion and proliferation.