• 文献标题:   Thermal Behavior of Graphene Oxide Deposited on 3D-Printed Polylactic Acid for Photothermal Therapy: An Experimental-Numerical Analysis
  • 文献类型:   Article
  • 作  者:   VENCE J, GIL C, GONZALEZRODRIGUEZ L, LOPEZALVAREZ M
  • 作者关键词:   graphene, phototherapy, simulation, laser, pla
  • 出版物名称:   JOURNAL OF FUNCTIONAL BIOMATERIALS
  • ISSN:  
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.3390/jfb14020080
  • 出版年:   2023

▎ 摘  要

The present work evaluates the thermal behavior of graphene oxide (GO) when deposited on 3D-printed polylactic acid (PLA), in order to develop a medical device for photothermal therapy applications. An experimental-numerical analysis was performed to assess the photothermal conversion capacity, based on the power emitted by a NIR (785 nm) laser, and the subsequent temperature distribution on the GO-PLA material. The influence of the deposited mass of GO and the PLA thickness was studied through 40 different scenarios. The results estimated a value of photothermal conversion efficiency of up to 32.6%, achieved for the lower laser power density that was tested (0.335 mW/mm(2)), and a high mass value of deposited GO (1.024 x 10(-3) mg/mm(2)). In fact, an optimal mass of GO in the range of 1.024-2.048 x 10(-3) mg/mm(2) is proposed, in terms of absorption capacity, since a higher mass of GO would not increase the conversion efficiency. Moreover, the study allowed for an estimation of the thermal conductivity of this specific biomaterial (0.064 W/m center dot K), and proved that a proper combination of GO mass, PLA thickness, and laser power can induce ablative (>60 degrees C, in a concentrated area), moderate (50 degrees C), and mild (43 degrees C) hyperthermia on the bottom face of the biomaterial.