▎ 摘　　要

In 50 degrees C conditions, the gold nanoreaction of HAuCl4-H2O2 is very slow, graphene oxide (GO) exhibited strong catalysis on the nanoreaction to form gold nanoparticles (AuNPs) with strong surface-enhanced Raman scattering (SERS) activity at 1614 cm(-1) in the presence of molecular probes of Victoria Blue (VB4r). The SERS intensity increased with the GO increasing due to formation of more AuNPs. The ferritin antibody (Ab) can bind to GO surface to form Ab-GO that can inhibit the nanocatalysis. When ferritin (Ag) existed, the produced immunocomplexes of Ab-Ag are separated from the GO surface, which led to the recovery of GO catalysis. The enhanced SERS signal Delta I1614cm-1 is linear to ferritin concentration in the range of 0.017-1.02 ng/mL. Accordingly, a new SERS quantitative analysis method was established for detection of ferritin, based on the regulating GO nanocatalysis. (C) 2018 Elsevier B.V. All rights reserved.