▎ 摘　　要

The anti-cancer drug loaded nanocarrier of functionalized graphene oxide (GO) with chitosan (CS) and sodium alginate (SA) was prepared successfully through electrostatic self-assembly process. The anticancer drug doxorubicin hydrochloride (DOX) was incorporated into the nanocomposites and the resulted DOX-loaded products displayed significant pH-dependent drug release behaviors. The modification of GO with CS and SA increased the solubility of both GO and DOX loaded GO nanocomposites as well as limited the undesired non-specific adsorption of protein in physiological conditions. Additionally, the GO-CS/SA nanocomposites could be internalized by MCF-7 cancer cells and the DOX loaded compositions displayed a remarkable cytotoxicity to the tumor cells. Therefore, the GO-CS/SA nanoparticles proved to be potential materials for delivery of anti-tumor drugs. (C) 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved.