▎ 摘　　要

Carboxyl graphene modified CuxO/Cu electrode was fabricated. The bare copper electrode was firstly anodic polarized in 1.0 mol/L NaOH solution in order to get CuxO nanoparticles, then the carboxyl graphene (CG) was electrodeposited on the CuxO/Cu electrode by cyclic potential sweeping. The electrocatabitic oxidation behaviors of calcium folinate (CF) at the graphene modified CuxO/Cu electrode were investigated by cyclic voltammetry. A positive scan polarization reverse catalytic voltammetry was used to obtain the pure catalytic oxidation current. The graphene modified CuxO/Cu electrode was served as the electrochemical sensor of CF, a highly sensitivity of 22.0 mu A.(mu mol/mu L)(-1) cm(-2) was achieved, and the current response was linear with increasing CF concentration in the range of 2.0 x 10(-17) mol/L to 2.0 x 10(-5) mol/L, which crossed three orders of magnitude, and the detection limit was found 7.6 x 10(-8) mol/L (S/N=3). In addition, the proposed sensor was successfully applied in determination. of CF in drug sample.