• 文献标题:   A Bioelectronic Platform Using a Graphene-Lipid Bilayer Interface
  • 文献类型:   Article
  • 作  者:   ANG PK, JAISWAL M, LIM CHYX, WANG Y, SANKARAN J, LI A, LIM CT, WOHLAND T, OZYILMAZ B, LOH KP
  • 作者关键词:   graphene, lipid bilayer, membrane disruption, bioelectronic interface, biomolecular doping, ionic screening
  • 出版物名称:   ACS NANO
  • ISSN:   1936-0851
  • 通讯作者地址:   Natl Univ Singapore
  • 被引频次:   93
  • DOI:   10.1021/nn1022582
  • 出版年:   2010

▎ 摘  要

The electronic properties of graphene can be modulated by charged lipid bilayer adsorbing on the surface. Biorecognition events which lead to changes in membrane integrity can be monitored electrically using an electrolyte-gated biomimetic membrane-graphene transistor. Here, we demonstrate that the bactericidal activity of antimicrobial peptides can be sensed electrically by graphene based on a complex interplay of biomolecular doping and ionic screening effect.