• 文献标题:   Fast and Simple Preparation of a Sensor Based on Electrochemically Reduced Graphene Oxide (rGO) for the Determination of Zopiclone in Pharmaceutical Dosage by Square Wave Adsorptive Stripping Voltammetry (SWAdSV)
  • 文献类型:   Article
  • 作  者:   NAVARRO F, SEGURA R, GODOY F, MARTI AA, MASCAYANO C, AGUIRRE MJ, FLORES E, PIZARRO J
  • 作者关键词:   electrochemically reduced graphene oxide, electrochemical analysi, zdrug, zopiclone, molecular dynamic
  • 出版物名称:   ELECTROANALYSIS
  • ISSN:   1040-0397 EI 1521-4109
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1002/elan.202200357 EA NOV 2022
  • 出版年:   2023

▎ 摘  要

The interactions of zopiclone with electrochemically reduced graphene oxide (rGO) modified electrode were examined. A comparison of GC/rGO and glassy carbon electrode (GC) by electrochemical impedance spectroscopy and scanning electrochemical microscopy (SECM) shows that the modified surface is much less conductive than GC. The role of rGO is to act as a site of specific adsorption of the analyte. Molecular dynamics showed that the monoanionic form of zopiclone presents more interactions with defects of rGO. The analytical methodology allowed obtaining a linearity of 10-130 mu g L-1, with a limit of detection of 2.14 mu g L-1 using SWAdSV at pH 10.0.