▎ 摘　　要

Rutin, as a biological flavonoid glycoside, has very important medicinal value. The accurate and rapid detection of rutin is of great significance. Herein, an ultrasensitive electrochemical rutin sensor based on & beta;-cyclodextrin metal-organic framework/reduced graphene oxide (& beta;-CD-Ni-MOF-74/rGO) was constructed. The obtained & beta;-CD-Ni-MOF-74 was characterized by X-ray diffraction spectroscopy (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and nitrogen adsorption and desorption. The & beta;-CD-Ni-MOF-74/rGO presented good electrochemical properties benefiting from the large specific surface area and good adsorption enrichment effect of & beta;-CD-Ni-MOF-74 and the good conductivity of rGO. Under optimal conditions for the detection of rutin, the & beta;-CD-Ni-MOF-74/rGO/GCE showed a wider linear range (0.06-1.0 & mu;M) and lower detection limit (LOD, 0.68 nM, (S/N = 3)). Furthermore, the sensor shows good accuracy and stability for the detection of rutin in actual samples.